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Thus, a prospective multicentre patient-based study design is needed to confirm these findings.
Results from these analyses, although preliminary, confirm our hypothesis that a pedigree-based study design is more powerful than designs based on data from unrelated cases and controls, and that collapsing methods are more powerful than single-marker analysis.
Family-based study design is commonly used in genetic research.
Further research, especially in studies with prospective population-based study design, is necessary to assess in detail what events in women's life lead to increased IMT or CP.
In addition, a questionnaire-based study design is prone to recall bias either by over- or underreporting family members with type 1 diabetes.
The family-based study design is robust to potential population stratification and particularly useful when sampling over such a wide geographic area.
First, we used a regional population based study design which may not be representative of other regions in the United States; however, the use of population based data at the regional level affords us considerable power, with stable estimates.
The incidence of AEs based on study design is shown in online supplementary table S5.
Therefore, to obtain valuable findings from observational study MAs, adequate assessment based on the correct study design is essential.
The study design is based on Survey model.
The qualitative study design is based on an earlier developed theoretical framework of extended interaction.
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