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In theory, a family based study design and genome sequencing can embrace the search for rare variants with both high and medium effect size, whether monogenic or oligogenic.
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This warrants a new paradigm that uses an ecological network-based study design and analysis tools.
The population-based study design and high overall response rate (80%) minimized potential selection bias.
First, the population-based study design and the high participation rate minimize potential selection bias.
The present results are strengthened by the population-based study design and the large number of participating children.
The large sample size, the population-based study design, and the long follow-up period are strengths of our study.
The main strength of our study includes its randomly-sampled population-based study design and the large sample size.
Our study's strength derives from its population-based study design and the uniform management of affected patients by uro-oncologists (Moore, 1995).
The relatively large sample size, population-based study design, and availability of both genotyping and NSAID information are the strengths of the study.
Our population-based study design and high response rate enhance the generalizability of our findings, and this represents a primary strength of our study.
A number of strengths support the current study, including the large sample size, the population-based study design and comprehensive collection of clinical and demographic data.
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