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Mechanism based studies suggest that these compounds inhibit either one or in some cases, both the targets.
Sleep state is known to impact the pathophysiology of several diseases including asthma, and vaccine based studies suggest that sleep can alter immune function [ 12, 13].
Recent population based studies suggest that the specialised cardiac test most commonly ordered before major non-cardiac surgery is resting echocardiography.
Recent population based studies suggest that up to 32%% of patients have a germline mutation in one of the known common susceptibility genes [ 9].
Therefore our in vitro and cell based studies suggest that of all of the potential substrates examined CRMP2 phosphorylation at Ser522 is most worthy for investigation as a surrogate marker for altered CDK5 activity in tumour tissue.
Data from hospital-clinic based studies suggest that patients with rheumatoid arthritis (RA) have a reduction in areal bone mineral density (BMDa) at both the hip and spine compared to non-RA controls [ 1- 4].
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Surface plasmon resonance based studies suggested that while pep14 exhibited affinity to human and rabbit IgM, pep14 failed to interact with mouse IgM.
Healthy older people volunteering for participation in research in response to advertisements are often fitter than the older population at large, but interestingly the incidence of falls in our control group was very similar to that found in most community based studies, suggesting that the control group was reasonably representative, despite the limitations of using this recruitment method.
These results underline findings in large population based studies suggesting that physical activity level is inversely related to mortality in both breast cancer and prostate cancer survivors [ 22- 24].
Of an estimated half a million people affected in the UK, estimates from population based studies suggests that less than half have been diagnosed [ 4].
Despite these attempts at validation, population based studies suggested that although some of these instruments were well suited to literate and well-educated subjects, their content and format were less appropriate for general use in Pakistan [ 21].
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