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Recent relatively high throughput transgenic mice assay based studies generated the genome-wide experimentally validated data set for hundreds of human enhancers.
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These carefully conducted studies generated the evidence base demonstrating that oral amoxicillin was both superior to cotrimoxazole and equivalent to injectable penicillin for treatment of chest-indrawing pneumonia.
Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in established clinical markers.
A limited number of evidence based studies often generating contradictory results have led to use of inconsistent therapeutic measures leading to suboptimal care.
The performance of the operator is translated to two metrics – margin-of-failure and available-time to respond to process events – which can be calculated using process operations data that can be generated from training simulator based studies.
5 Using data generated from a population based study, we examined the possible utility of measuring viral persistence over about a one year interval (9-21 months) and the risk of precancer and cancer over the subsequent years of follow-up.
Hospital controls might introduce selection bias if they do not reflect the smoking habits in the study base that generated the cases in our study.
These studies generated inconsistent findings, were based on small populations, and focussed on short-term post-cholecystectomy outcomes (<5 days post-operatively) only.
DKW and KPB devised the study; MAO generated the query based on ICD-9-CM codes; NMW and VJF assisted in study design; KPB and JM collected and analyzed the data, and wrote the manuscript; all authors critically reviewed the final draft of the manuscript.
SD is the postdoc on the study, and generated the first draft of this manuscript based on the study protocol.
Therefore, an ecologic study needs to be followed by an individual risk factor study based on hypotheses generated by the ecologic results, with adjustment for individual risk factors and confounders.
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CEO of Professional Science Editing for Scientists @ prosciediting.com