This, prompted us to establish an integrated high-throughput screening cell-based strategy for identifying small molecule cell cycle modulators, for use in dissecting the mechanisms of cancer cell division, and for developing novel cancer therapies.
"We will rely heavily on our established, science-based strategy for identifying and selecting appropriate projects to receive funding," says Jeff Trandahl, CEO of the Washington, D.C.-based D.C.-basedorganization
This makes the ICA-based strategy for identifying the site of origin sensitive to imperfect de-convolution of the tumor expression profiles and often leads to misidentification of the site of origin as the surrounding tissue.
In this paper, we employ a biochip-based strategy for identifying post-translational modifications that regulate the actions of histone modifying enzymes, and we show specifically that acetylation of H3 Lys14 by the lysine acetyltransferase p300/CBP associated factor (PCAF) is inhibited by methylation or deimination of the distal residue H3 Arg8.
We use a random mutagenesis based strategy to successfully identify variants of the AcrB protein for improved 1-hexene tolerance.
A strategy for identifying piezoviscosity based on image analysis and numerical identification is devised in two steps.
From spatial perspective, geographic targeting (GT) [ 9] provides a useful strategy for identifying people who need insurance most based on physical location.
Another strategy for identifying related gene pairs from the literature is to infer gene relatedness based on a common linkage to keywords.
Figure 8 illustrates the proposed strategy for identifying cellular signatures in in vivo data and its implications for in vivo microarray based studies.
