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gambiae were based solely on computational predictions from their genomic sequences.
The vast amount of available EST data allows expression analysis based solely on computational methods.
A more speculative analysis, including transcripts based solely on computational prediction, produced another 160 differentially expressed genes, three-fourths of which have no previous annotation.
Aside from interologs, DroID currently does not include interactions based solely on computational predictions, which may be found in other databases [ 36, 37].
Differential expression of high confidence transcripts correlated extremely well with known cancer genes and pathways, suggesting that the more speculative transcripts, largely based solely on computational prediction and mostly with no previous annotation, might be novel targets in colon cancer.
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Genes based solely on ESTs or computational predictions were not included.
The identification of protein coding regions in de novo-sequenced eukaryotic genomes based solely on ab initio computational algorithms is prone to specificity and sensitivity issues due to the lack of validated gene training sets.
Based on our experience, we believe that the comparison of miRNAs and mRNAs expression profiles therefore provides a useful complement to pure computational predictions based solely on sequence information.
A genome wide functional analysis of the distribution of replication origins in budding yeast has shown significant agreement with a computational analysis based solely on the distribution of ARS-related motins in the yeast genome[4], [5].
Prior to the availability of ChIP-Seq and ChIP-chip data, computational approaches based solely on genomic sequences were used to identify enhancer regions.
We have proposed an information-driven theoretical approach which is an entropy fragment-based approach (EFBA), for the computational design of aptamer templates based solely on structural information of the biomolecular targets [ 11].
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