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Additional file 2: Experimentally based sensitivity score and model-based sensitivity score for treatments of ten signaling agents with and without consideration of miRNA expression data.

The Pearson correlation is used to compare the model-based sensitivity scores to the experimentally based sensitivity scores measured under the in vitro condition by Holbeck et al. [ 31].

HER2 status, ER status (based on ER score), and PR status were obtained from the clinical data provided on the M.D. Anderson website and used in the analysis of the effect of molecular variables on chemotherapy sensitivity prediction.

Based on sensitivity and specificity values for MEKK3, a total score cut-off value of 3 was defined as MEKK3 immunopositivity.

The parameters are sorted by the sensitivity scores (based on the original model) in decreasing order; * indicates original model parameters without a counterpart in the hybrid model.

Based on sensitivity and specificity analyses and the CART procedure, an FSFI total score of 26.55 was found to be the optimal cutoff score for differentiating women without sexual dysfunction from those with sexual dysfunction.

It is based upon parallel scoring and population tracking techniques.

The HIP pool construction, gDNA extraction, hybridization procedure, and calculation of sensitivity scores were based on the methods published by Pierce et al.

By this we get a calculated sensitivity score similar to the one from the sensitivity analysis, but based on the hybrid model and therefore denoted.

From this we calculated a sensitivity score similar to the one from the sensitivity analysis, but based on the hybrid model, and therefore denoted.

In the current study we defined the thresholds of severe, intermediate and slight sensitivity based on the scores of the three control strains mag1Δ, rev1Δ and rad14Δ, respectively.