Sentence examples for based screens have been from inspiring English sources
Techniques and assays for screening of small molecules with potential to modulate microRNA function and or action [16] apart from phenotypic or specific expression based screens have been increasingly being adapted for high-throughput screening strategies.
Many detergent based screens have been performed in the context of membrane protein structural biology.
In addition, poor compliance with selective risk factor based screening has been reported [ 29], so that not all colonized patients may have been detected.
A polymerase chain reaction based screen has been used to identify PI3Ks in the human breast using mRNA derived from cells and epithelial tissue from reduction mammo-plasty.
Currently, genetically encoded, sensor-based screens have been developed for AKG [ 40] and arginine [ 50], and a direct ethylene sensor could potentially be constructed based on the ethylene receptor in plants and cyanobacteria [ 51].
While cell-based screens have been used in purely empirical screening efforts, they can also be used as the basis of target identification or verification.
Cell-based screens have been widely used in drug discovery although historically, these assays are conducted using genetically diverse cell lines derived from human tumors [1], [2].
Viral-based screens have been introduced for their promise in expanding RNAi screens to models incompatible with conventional siRNA-based approaches.
High-throughput RNAi-based screens have been successfully used to identify synthetic lethal pathways with well-characterized tumor suppressors and oncogenes.
As in other anti-infective areas, target-based screens have been unsuccessful prompting investigators to adopt whole cell screening once more (Cole & Riccardi, 2011; Payne et al, 2007).
