A metabolizing enzyme toxicology assay chip (MetaChip) integrating drug metabolic toxicity and high-throughput cell-based screening was developed for anticancer chemotherapeutics.
A novel high throughput-enabled human cell based screen, Anthem's Genotoxicity screen, was developed to achieve higher specificity for predicting in vivo genotoxins by an in vitro method.
The screener was developed based on the findings of a literature review on available validated instruments that aim to determine patients health literacy related communication and navigation assistance experiences in health care delivery in the primary care practice.
Initial content for the training and screening tool was developed based on interviews with law enforcement leaders and a subsequent focus group.
A solvent screening criterion was developed based on the maximum product concentration attainable for the assessment of batch and semicontinuous multicomponent extractive fermentations.
Subsequently, a novel high-throughput screening method was developed based on precursor toxicity and used for ISPS directed evolution towards enhanced catalytic activity.
A number of paper based screening methods have been developed to identify hazardous alcohol consumption; these include instruments such as the Michigan Alcohol Screening Test [ 15], Paddington Alcohol Test [ 16], Fast Alcohol Screening Test [ 17] and the Alcohol Use Disorders Identification Test [ 18].
The second approach is based on an automated high throughput screening system for phototrophic microorganisms within Deepwell plates (robot screening), which was developed in house.
A method based on colony PCR was developed for rapid screening of class IIa bacteriocin-producing lactic acid bacteria.
In the FA patient fibroblasts, a robust high-throughput screening assay based on diamide sensitivity was developed, with an average Z′-score of 0.7.
Based on this model and the MUV datasets, SAFE (Scale for Assessing Figures of Effectiveness) an open, standardized, platform for the benchmarking of virtual screening methods was developed.
