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Therefore, population based screening could be improved by the introduction of primary hrHPV testing.
Altogether, internet based screening could be helpful to stimulate especially young men [ 23].
One approach for improving the sensitivity of FIT based screening could be to increase the number of samples tested, which is common practice for gFOBTs [ 3- 5].
Because HPV infection precedes the development of cervical intraepithelial neoplasia, 7 it is conceivable that HPV based screening could be performed with longer screening intervals, which in turn could result in more cost effective screening.
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Age-restricted FIT-based screening could be an attractive strategy therefore, not only for Ireland but also elsewhere.
In addition, bidirectional cell-based screening could be applied to other important biological pathways with dual functions in brain development and tumor invasion.
Symptoms-based screening could be a useful tool when other typical ovarian cancer symptoms are present but the index of suspicion is not sufficient to prompt referral or more expensive investigations.
However, the majority of GPs supported centrally organised delivery of CRC screening, as well as believing that population-based screening could be effectively performed by patients using home testing kits.
This contradicts the suggestion from a modelling study that home based screening could have an impact on chlamydia prevalence within a few years, 49 but supports an earlier UK expert opinion that register based chlamydia screening would not be effective.
Gene signature based screen could overcome these drawbacks effectively.
Additional benefits from screening could be surmised from this study.
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