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The strength of the study lies in the large population based sample and the uniform OA cutoff using TKR as a marker for the group that has the most severe form of the disease.
The strength of this study is the large population based sample and the unit record linkage to administrative data collections on claims for occasions of care and events such as hospitalisation.
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The strengths of this analysis lie in the large database, the probability based sampling, and the standardized methodology of the tri-annual data.
A proper test of the contending models of the architecture of the phenotype can only be undertaken by studying population based samples and analyzing measures that cover the full range of manifestations of the putative quantitative traits.
Primary headache disorders are common in this community based sample study and the burden of them is intense and massive.
The new quasi-random sampling strategy performs better than the radial based sampling strategy and the new random sampling strategy performs almost the same with the radial based sampling strategy.
The present study also has several strengths, particularly regarding the large population based sample of adolescents and the high participation rate which might offer an opportunity to generalise the results to other adolescent populations as well.
Future research should examine the psychometric properties in a population based sample, further improvements of the instrument and should apply other methods of validation.
These included the imputation process, the use of a population-based sample and the inclusion of repeat measures at different ages.
Important methodological strengths of the study include the large community-based sample and the prospective design.
Our study has strengths including a community-based sample, and the rigorous and detailed external validation approaches.
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