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A 5 mm Hg reduction in systolic blood pressure had almost identical effects on major cardiovascular events at different eGFR, with no difference between ACE inhibitor and calcium channel blocker based regimens compared with placebo (fig 2).
Overall, 21 major cardiovascular events were prevented for every 1000 participants treated (ACE inhibitor or calcium channel blocker based regimens) compared with placebo (number needed to treat (NNT) for preventing one event over an average of four years was 47).
The relative risk of cardiovascular events was 0.91 (95% confidence interval 0.81 to 1.02) in trials where controls had no exposure to folic acid based regimens, compared with 0.99 (0.93 to 1.06) in trials where controls did have some level of exposure, either through fortification or through comparator treatment.
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There were increased healthcare resource utilization costs for monitoring events, complementary therapies to manage side effects, and physician visits with chemotherapy-based regimens compared with hormone therapy.
No previous study was successful in demonstrating a statistically significant survival advantage in favour of platinum-based regimens, compared with platinum-free combinations.
The study was designed to detect a 33% difference in survival between the docetaxel-based regimens compared with the mitoxantrone regimen.
In addition, the incremental cost-effectiveness ratios (ICERs) of boceprevir-based regimens compared with treatment with peginterferon and ribavirin alone as well as for PR48 compared with no treatment were estimated.
However, DFS was improved with any maintenance compared with observation (hazard ratio 0.59, 95% confidence interval 0.48 0.74 with 1209 patients in 5 trials), although DFS was not statistically improved with ATRA-based regimens compared with non-ATRA regimens (hazard ratio 0.72, 95% confidence interval 0.51 1.01 with 670 patients from 4 trials).
These data corroborated the findings from an earlier study by Nachman et al. in which there was no difference in the GMCs in HIV-infected children, 71% of who were on protein-inhibitor based ART regimen, compared with a historical control group of HIV-uninfected infants.
A statistically significant 4-year disease-free survival advantage was detected for the 2 dose-dense regimens compared with the regimens administered every 3 weeks.
A higher SSI rate was observed among patients which received the ampicillin based regimen (11.5%) compared with those which received non-ampicillin based regimen (8.2%, p = 0.304, HR 1.4).
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