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Use of a single or multiple protease inhibitor based regimen was not associated with risk of hepatotoxicity in either naïve or experienced patient groups to a statistically significant extent.
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Age and administration of tamoxifen were found to be significant predictive factors of CIA, whereas docetaxel and navelbine based regimens were not associated with higher rates of CIA than epirubicin-based regimen.
When enterococci were also considered, all betalactam based regimens required combination with vancomycin or linezolid for a SAR > 95%%, whereas TGC based regimens were not compromised.
All of these results confirmed that subQ bortezomib-based VTD regimen was not inferior to IV route, with even an improved safety profile.
Protease inhibitor (PI) based regimens were reported by 16 studies.
When the comparison was made with triple therapy lasting 14 days and with bismuth based and non-bismuth based quadruple therapies, the sequential regimen was not significantly superior to any of these treatments.
A treatment regimen was considered inappropriate if the regimen was not a WHO recommended regimen.
e TDF/3TC/EFV regimen was not included.
But of course, the science was complicated and the regimen wasn't recommended for any or every patient.
In the adjuvant setting, the choice of treatment regimen is not modified based on the presence of such a predisposition.
However, long-term efficacy and safety of this regimen are not well defined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com