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This effect was more pronounced for ANOLEA and CHARMM based predictors which are more sensitive to small coordinate changes than ProsaII based predictors, data not shown.
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Thus these algorithms are not directly suited in modelling the applicability domain of kernel-based predictors, which are working in a extremely high dimensional implicit feature space.
Our nomogram is based on few predictors, which are all available from routine clinical work.
In such a situation, the predictors (which are based on respondent's characteristics) would not correspond with the outcome (which is based on the relatives' behavior).
Results from the experiments suggest that the proposed approach yields better prediction performance than other state-of-the-art rating predictors which are based on the conventional Artificial Neural Network, Fuzzy C-Means, and Support Vector Machine approaches.
The fitted GLM may contain some predictors which are redundant in nature and are required to be eliminated from the model based on the observed data.
For these cross-covariance functions, peaks to the right of zero delay indicate that neuron B fired before neuron A. Since neural response correlation may be due to stimulus effects, we also calculated shift predictors, which were based on two presentations of the ripple stimulus (Fig. 2, gray curves).
In the following stages, we expanded the initial sets while getting significantly better predictors which were based on 2, 3 or more genes.
It was shown that health care professionals' consensus based selection of key predictors reflected most statistically selected predictors but also included additional predictors which were not identified by statistical selection.
We devised an approach to do this, based on creating simulated datasets in various different ways which selectively removed variation in the predictors which were not of interest.
This study is based on a large national cohort using a longitudinal design and with information on several adolescent predictors, which is a clear advantage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com