Availability of structural information was crucial as we wanted to base our identification of loop 8/9 in the context of the position it occupies in the structure.
Given the taxonomic complexity of the genus [ 58, 85, 86], and the poorly defined diagnosis available for A. mollis, we based our taxonomic identification of specimens on a combination of external and internal morphological characters (e.g., a robust braincase, short rostrum, zygomatic plate broad and not inclined [ 24, 57, 87, 88]).
The characterization of the host star Kepler-61 is based upon our identification of a spectroscopically similar star located 4.9 pc from Earth.
Based on our identification of a PC-esterase domain in PMR5 and ESKIMO1 we suggest that in both the cases the primary biochemical role of the esterase is modification of the cell-wall glycan properties by removal of acyl groups.
Based on our identification of functional gap junctions in CSCs and the efficacy of gap junction inhibitors on attenuating CSC maintenance, we wanted to determine which connexins were responsible for these effects.
We based our approach to identification of cohabiting couples on an analysis of national survey data.
Our identification of BCIS cases was based on patient pathology reports.
The existing literature base has also been extended, given our identification of a strong association between exposure to two or more senior science subjects (a marker of breadth of knowledge) and first year academic outcomes.
Therefore, rather than relying solely on such analyses, we base our inferences on the identification of novel homologs via HMMER searches combined with phylogenetic results.
However, it is possible that this may not be a reliable indicator of a familial cancer phenotype generated by germline mutations in EP300, given that our selection criteria were based on identification of mutations in only a small number of cancers [ 12, 13].
