Sentence examples for based only on persistence from inspiring English sources
The chemicals classified as Cat 1 based only on persistence of effects have mean CO scores of similar grade as the Cat 2 chemicals that were classified based on COMaj ≥ 1 (Fig. 1a).
Among the Cat 1 chemicals evaluated, 36 65 % (depending on the database) were classified based only on persistence of effects, with the remaining being classified mostly based on severe corneal effects.
Of note, a substantial proportion of the Cat 1 chemicals is currently being classified based only on persistence of conjunctiva effects (6.5 % (4/62) in the RCD and 9.3%% (12/129) in the NCD).
Another important difference between the liquids and solids of the RCD was observed for the Cat 1 chemicals classified based only on persistence of effects, with the under-prediction rate as Cat 2 obtained for the liquids being almost 12%% higher than for the solids.
Certainly, it is known that the under-predictions for Cat 1 chemicals obtained with organotypic methods like BCOP and ICE, which were developed to detect immediate severe effects, are more likely for chemicals classified in vivo based only on persistence of effects than for those classified based on severity (ICCVAM 2006a, b, 2007).
Importantly, chemicals that were classified Cat 1 based only on persistence of effects in both the RCD and NCD have individual animal mean CO scores that are mostly below 3 (in 74/76 rabbits) and mean IR scores that are mostly below 1.5 (in 72/76 rabbits), i.e. below the CO and IR Cat 1 classification thresholds (Fig. 1).
Consequently, it was not possible to estimate the resampling probabilities for the chemicals that were classified based only on CO = 4 (observed any time during the observation period, before day 21) or persistence of a tissue effect.
It was therefore not possible to estimate the resampling probabilities for the chemicals that were classified based only on CO = 4 (observed any time during the observation period, before day 21) or persistence of a tissue effect.
Tying runs on base, only one out.
Under-predictions as NC were actually only observed for a small proportion of the simulated chemicals that were classified based on persistence only (0.1%% or 13/10,000) (Table 10).
