Although the distribution of exons is just a snapshot of the present day world, fitting it to a model based on well characterized mathematical functions may provide insights into the evolution of exon-intron structure.
In this context, public-private partnerships based on well characterized and openly shared biological resources and data repositories, taking into account issues of intellectual property rights and active patient participation, individually and through patient organizations, are vitally important [ 7].
First, we analyzed our array data based on well-characterized markers for endodermal subsets (Fig. 4).
Therapeutic decisions based on well-characterized biomarkers are common in other fields (for example, oncology) where mechanistic rationale and extensive clinical data exist.
Compared to Western countries, women in North Africa are less likely to be prognosticated and treated based on well-characterized markers such as the estrogen receptor (ER), progesterone receptor (PR) and Her2.
The present study was undertaken to apply the SLICC-12 criteria and compare them with ACR-82, ACR-97 and Fries and Holman's diagnostic principle (hereinafter referred to as 'Fries'), based on well-characterized SLE cases included in a Swedish regional SLE register as well as on autoantibody-positive individuals referred to our rheumatology unit on the suspicion of systemic autoimmune disease.
The epidemiology of DSPS is still in its infancy, and while the present study contributes to an understanding of the prevalence and correlates of the symptoms, more studies are needed to bridge the gap between our knowledge based on well-characterized DSPS in clinical trials, and knowledge from epidemiological studies.
Also, studies on this issue based on a well characterized study population as the present one including a great number of phenotypes, risk factors and comorbidities are scarce.
The study is based on 21 well characterized carbons, whose external and microporous surface areas, Se and Smi, have been determined by a variety of independent techniques.
IL-6 was chosen for further investigation to determine the signaling pathway that may underlie altered expression based on its well characterized role in hematopoiesis.
Based on the well characterized responses of the fluorescent probe we utilize in this study [30], [31] we are able to conclude from our observations that AHLs are capable of direct insertion into biological membranes in the micromolar concentration range.
