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It has been also suggested, based on viral sequence analysis, that during evolution, plant-infecting viruses (previously known as plant circoviruses and recently reclassified in the genus Nanovirus) switched hosts to infect a vertebrate and then recombined with a vertebrate-infecting virus [16].
These observations indicated the promise of our method in predicting activated disease pathways based on viral sequence.
What is the probability that outbreaks with anecdotal links had a transmission link based on viral sequence data?
A systematic, open, and timely global surveillance system based on viral sequence data would be a powerful tool in pandemic risk assessment.
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However, recent developments suggest that specific responses may be based on viral sequences inserted into the host genome.
Thus, a method to estimate the infection duration based on viral sequences would be attractive, given the abundance of HIV sequence data from genotypic drug resistance tests.
To prevent catastrophic outcomes of influenza virus pandemics with newly evolved strains, efforts are underway to develop so-called universal flu vaccines based on viral sequences that are highly conserved across heterologous strains.
Based on viral RNA sequence, there are at least 2 viral genotypes of BVDV that can be further divided into subgenotypes [ 2, 3].
Another important motivation is to find a feature set based solely on viral sequence and not requiring a priori information obtained via virus-specific in vitro cell assays.
Nonpolio HEV typing based on viral protein (VP) 1 sequences has been developed and correlates well with antigenically defined serotypes (2 ).
To overcome this problem, strategies based on viral vector-mediated transfer of miRNA sequences targeting the AAT gene have been developed (Mueller et al, 2012).
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