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Thousands or millions of trials may be necessary to yield a candidate configuration, based on very simplified performance assessment (e.g., analytical solutions, impulsive velocities, response surface models etc).
This procedure differs from those previously reported, which generally follow an empirical approach or are based on very simplified models of the physics associated with moving beds.
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Even this simplified evaluation can be based on very complex considerations.
Based on a very simplified example, this paper discusses this concept for the particular case of the characterization of the nanoparticle protein corona.
But Jean-Marcel Dorioz, director of the INRA limnology research unit at Thonon-les-Bains, France, feels that the "model was based on a very simplified view" of phosphorus leaching.
As addition to the developed concept, the authors have designed a computer simulation of somatic cancer evolution of genetically unstable cells based on a very simplified mechanism of unequal sister chromatid exchange (USCE) in order to provide a crude impression of possible restrictive or permissive effects of the cancer genome architecture on cancer cell evolution.
Both the decision on TP and FP at the segmentation setup and the state model in the Kalman filter is based on a simplified but very similar X-ray interaction model as the model used for synthetic radiographs.
It is important to highlight that the present population-based analysis is based on a simplified case definition for GBS.
Here we hypothesize that the robust properties of differentiation are rather the outcome of the interaction of very many genes, so our model is based on a simplified dynamical model of genetic regulatory networks, namely noisy random Boolean networks (NRBNs for short), which actually allow simulations of large networks [12].
Very fine modelizations are difficult to treat for our sequential solver, based on the simplified transport equations, in terms of memory consumption and computational time.
On the other side of the topology-driven spectrum, logical models are based on a simplified (on/off) representation of the signalling transduction mechanism and thus, are applicable to very large topologies [ 19- 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com