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Confidence intervals (CI) for rates and rate-ratios were calculated based on variance estimates derived from the Poisson distribution.
Tests of fixed effects were based on variance estimates using the restricted maximum likelihood (REML) method and denominator degrees of freedom approximated by the method of Kenward and Roger [ 36].
Based on variance estimates from similar Swedish data on 4-year-olds, we have estimated that the statistical power is approximately 90% to detect a mean BMI unit difference of 0.3 kg/m at four years of age.
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Calculation of heritabilities and genetic correlations were based on variances estimated by the linear mixed model (1).
The calculations were based on variance components estimated from three different studies: women with a distal fracture of the forearm (n = 22); patients with pituitary insufficiency (n = 21); and patients with primary hyperparathyroidism (n = 21).
All the simulated datasets based on variance components estimated from the real maize datasets used the three multiples of the exact same SD: 6.977 for the small and 7.340 for the large datasets.
Overall, the estimated phenotypic correlation based on variance components was linearly related to the sample phenotypic correlation for pairs of environments having positive sample phenotypic correlations.
For this reason, all models were fitted using Generalized Estimating Equations (GEE) methods [57], and associated inferences were based on robust variance estimates accounting for such correlations.
Estimates based on variances are associated with greater uncertainties than estimates based on means.
Power calculations based on the variance estimates of regional CBF measurements suggest that comparatively small cohorts are adequate.
95% CIs were calculated based on these variance estimates.
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