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Ideally, we would conduct a prospective study based on unselected cases.
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We may compare the results for heritable cases from the present study with those from other studies based on unselected groups of heritable cases.
Finally, single institution studies, also when based on unselected populations, should be interpreted with caution.
Our study is underpowered to detect a small effect size, as observed in GWAS based on unselected population.
4 5 Patients with cardiovascular disease report poorer HRQoL than the general population, but the available literature is rarely population based 5 9 and only few studies based on unselected general populations are available.
This new study (Seguí et al, 2011) was based on unselected microsatellite-stable CRC patients, without information regarding age of tumour onset or familial history, and the control population was not described.
In Spain, a personal disability index has been proposed, based on unselected disabilities registered in the 1999 NDS and taking into account the severity and number of hours of personal help received per week [ 11].
We conducted population surveys on unselected cases of breast cancer, prostate cancer and colon cancer.
This study is based on nation-wide register data covering more than a decade, and we present results from a largely unselected population of more than 8000 monozygotic and 15 000 dizygotic same sex twins.
This analysis is based on 313 cases.
Results are based on complete cases only.
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