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Heritability estimates for these traits are generally based on twin correlations, while effects of assortative mating are not considered.
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The order of model fitting is based on the twin correlations and cross-twin cross-trait correlations.
The study populations were based on twin cohorts enrolled in the Danish Twin Registry, one of the oldest and most complete population-based twin registries in the world.
Heritability estimates based on twin studies generally fall in the 40 60 percent range.
An assumption of quantitative genetic analyses based on twin data is that variances are equal for MZ and DZ twins.
Based on twin studies, the heritability of breast cancer has been estimated to be 27% [ 11].
The estimated heritability based on twin studies is 71% for advanced forms of this disease (24).
For comparison the table also shows estimates of heritability based on twin studies for these traits.
Based on twin studies, colorectal cancer (CRC) displays ∼35% heritability (1).
Although lack of information on zygosity prevented the calculation of heritability based on twin data, the higher RR shared by same-sex (partly monozygotic) twins compared to opposite-sex (exclusively dizygotic) twins supports a genetic contribution.
As shown in Table 3, ACE model-fitting results are consistent with estimates based on the twin correlations in Table 2.
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