Sentence examples for based on trough levels from inspiring English sources

According to these criteria, the prediction of AUC0 24 based on trough levels was biased (yet precise).

Of those, 15% (LCPT) versus 9% (tacrolimus twice daily) of adjustments were done based on trough levels ≥25% outside of the preconversion trough.

Patients were randomly assigned to receive intravenous linezolid (600 mg every 12 hours) or vancomycin (15 mg/kg every 12 hours, with the dose optimized, based on trough levels and renal function) for 7 to 14 days.

The initially prescribed total daily dose for both tacrolimus formulations is 0.10 mg/kg/day as per standard hospital protocol with adjustments based on trough levels first obtained on postoperative Day 2 or 3.

The hypothetical model population was assumed to be similar to the population included in a recent phase IV, prospective, double-blind, controlled, multicenter, international clinical trial of IV linezolid (600 mg every 12 hours) or IV vancomycin (15 mg/kg every 12 hours, dose-adjusted based on trough levels and renal function) for the treatment of MRSA NP [ 16].

8 Of note, the clinical response rate with vancomycin therapy in the ZEPHyR trial was lower than that with linezolid therapy even though the vancomycin dose was higher than that utilized in the study by Song et al. In the ZEPHyR trial, vancomycin therapy was initiated at a dose of 15 mg/kg as recommended by current guidelines 9 and adjusted based on trough levels.

In light of that variability and the relationship between systemic exposure and clinical benefit and toxicities, dose adjustments based on trough plasma concentrations may provide a method to optimise therapy with pazopanib by maintaining therapeutically effective blood levels, while minimising AEs whenever possible.

The estimation of FEV1% predicted was based on trough FEV1.

*Accumulation index was based on trough concentration after first and last dose.

The taspoglutide mean plasma concentrations, based on the trough levels between weeks 3 and 8, were 41.2, 77.5, and 96.6 pmol/l for the 5, 10, and 20 mg once-weekly groups and 29.7 and 51.8 pmol/l in the 10 and 20 mg once every 2 weeks group.

Units were classified as broad- or narrow-spiking based on trough-to-peak time and the slope of the waveform 0.5 ms after the initial trough as described (Niell and Stryker, 2008).