Sentence examples for based on trough concentration from inspiring English sources

*Accumulation index was based on trough concentration after first and last dose.

In light of that variability and the relationship between systemic exposure and clinical benefit and toxicities, dose adjustments based on trough plasma concentrations may provide a method to optimise therapy with pazopanib by maintaining therapeutically effective blood levels, while minimising AEs whenever possible.

The estimation of FEV1% predicted was based on trough FEV1.

According to these criteria, the prediction of AUC0 24 based on trough levels was biased (yet precise).

Of those, 15% (LCPT) versus 9% (tacrolimus twice daily) of adjustments were done based on trough levels ≥25% outside of the preconversion trough.

We, therefore, usually adjust the daily dosage of TAC based on the trough concentration in order to avoid adverse effects due to this drug.

Additionally, all except three of the LSS examined gave a better prediction of the complete AUC0 12 in comparison with LSS based on a trough concentration C0 and C12 (mean 62%).

The results were also compared with the predictability of the regression equation based on the trough concentrations C0 and C12 of these 37 patients.

Units were classified as broad- or narrow-spiking based on trough-to-peak time and the slope of the waveform 0.5 ms after the initial trough as described (Niell and Stryker, 2008).

The dose of CsA was adjusted individually based on the blood trough concentration of CsA and renal function.

Dose adjustments based on initial trough serum concentrations should therefore also take the maturation of renal function into account.