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Current guidelines for the antimicrobial therapy of melioidosis are based on trials conducted in adult patients.
Failing that, we will forever be stuck in a time warp based on trials conducted 20 30 years ago.
However, the results presented here are based on trials conducted at a single experimental site with a single fertilization treatment.
The model parameters were selected based on trials conducted on a previously-reported set of Jamaican families [ 18].
Collaborative care can reduce depression in people with LTCs but evidence is largely based on trials conducted in the United States that adopted separate treat to target protocols for physical and mental health.
Several studies of azithromycin-chloroquine have been conducted outside of sub-Saharan Africa and are included in Table 2. Based on trials conducted in India, Indonesia and Colombia/Surinam, regimens containing 500 mg azithromycin plus 600 mg chloroquine for 3 days may contain insufficient azithromycin to achieve 95% APR at day 28.
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Given that our prevalence estimates are based on a large North American cohort study, 10 our estimates of efficacy based on randomised trials conducted throughout the world, and that Canada has publicly funded healthcare and relative costs that are likely similar to Europe, we think that our results are likely to be valid in other countries.
A number of cultivars with stably low accumulation of either Cd or As in the grain were identified based on the trials conducted in multiple sites and seasons (Table 3).
Traditionally, pharmaceutical companies prescribe the "optimal" dosing information based on clinical trials conducted at a population level of the general public and patients.
Proposed sensitivity analysis based on trial quality was not conducted because of the small number of trials identified.
After 50 min the chambers were sealed and oxygen consumption measurements were made over 184 min. Fifty min was considered to be an appropriate settling period to eliminate any effects of handling stress, based on trial experiments that we had conducted and other studies (e.g., [42], [43]).
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