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Proposed sensitivity analysis based on trial quality was not conducted because of the small number of trials identified.
Subgroup analysis based on trial quality (low risk of bias versus high risk of bias) and cohort enrolled (hypertension versus non-hypertension trials) did not make any noticeable difference for the above analyses (table 3).
The results were largely similar in a sensitivity analysis based on trial quality and when the EUROMAX data was considered as a comparison trial of unfractionated heparin plus GpIIb/IIIa inhibitor (data not shown).
Analyses were performed (a) based on trial quality; (b) considering the EUROMAX trial as a trial of unfractionated heparin plus GpIIb/IIIa inhibitor; and (c) using a restricted network comparing unfractionated heparin plus GpIIb/IIIa inhibitor, unfractionated heparin, and bivalirudin and excluding trials comparing LMWH plus GpIIb/IIIa inhibitor and fondaparinux.
Similar(56)
The quality adjustment of producers based on trial and error discussed in this paper can be relevant when the economy lacks a sufficient number of commodity markets for all the attributes (and therefore quality) to be coordinated indirectly.
Since there are still no general guidelines for growing high quality protein crystals, these steps are often based on trial and error, which consumes time, money and manpower.
Given these circumstances, the study posits that producers follow a quality adjustment process based on trial-and-error, that is, they adjust the quality in accordance with demand in order to predominate the product market with improved quality.
We based the evidence synthesis on trial quality and statistical differences in the between-group comparisons in each intervention category.
There is low-quality evidence, based on one trial, that BVA can significantly reduce pain, morning stiffness, tender joint counts, swollen joint counts and improve the quality of life of patients with RA compared with placebo (normal saline injection) control.
Establishing efficient quality control is challenging as it bases on trial and error to accumulate knowledge on optimal culture conditions for therapeutic applications.
Overall, the results based on high quality trials seemed similar to all other trials.
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