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Our findings may lay the groundwork for future therapeutics based on transplantation of genetically engineered human primary cells for treatment of diseases affecting kidneys and potentially other tissues.
Thus, therapies based on transplantation of neural stem cells from exogenous sources have been developed recently [54].
Altogether, these factors contributed to the loss of bioluminescence imaging signals over time and the lack of long-term benefit in cardiac function, which is also consistent with recent findings based on transplantation of hESC-derived cardiomyocytes [25], [41].
In this study, we specifically focussed on two broadly accepted AML mouse models based on transplantation of stem/progenitor cells retrovirally transduced with the oncogenic fusion-proteins MLL-ENL and MOZ-TIF2, respectively [6], [7], [20].
Therefore, the notion of cellular cardiomyoplasty, based on transplantation of various cell types including bone marrow stem cells [1], [2], dermal fibroblasts [3], fetal or neonatal cardiomyocytes [4], [5] and skeletal myoblasts [4] [14], has been proposed, with the expectation that such cells would differentiate and/or trans-differentiate into cardiomyocytes.
The aim of this study was to evaluate the safety and the feasibility of a therapeutic protocol for advanced liver cirrhosis based on transplantation of hBTSCs.
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Based on transplantation experiments, the function of leo was reported to be required in melanophores and in xanthophores (Maderspacher and Nusslein-Volhard, 2003).
We describe a novel approach to immunotherapy based on a transplantation of low numbers of antigen-expressing hematopoietic stem cells (HSCs) following nonmyeloablative or partially myeloablative conditioning.
These studies were followed by the development of novel approaches based on the transplantation of primordial germ cells (PGCs) into the celomic cavity of fish hatchlings and/or the blastodisc of embryos (and the ability of the PGCs to migrate towards and find their way into the germinal ridges) [6], [7].
The present article is focused on examining the characteristics of the blood supply of a new tumour model based on the transplantation of ES cells into the mouse seminiferous tubules.
Models based on the transplantation of human cells into a host of another species (xenografts) are a powerful system to study disease-related human alterations in the context of a whole animal.
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