According to the U.S. EPA, "the RPF method uses empirically derived scaling factors that are based on toxicity studies of the effect and exposure conditions of interest in the assessment," whereas the TEF is based on "extensive mechanistic information that shows all the toxic effects of concern share a common mode of action" (U.S. EPA 2000).
Molecules of interest may prove their ability to influence the disease outcome in animal models and must respond to a set of criteria based on toxicity studies, ease of administration, the cost of their synthesis, and logistic for clinical use to validate it as a good candidate in a therapeutic perspective.
From these data, doses were selected for the quintary mixture study based on toxicity, survival, range of response, and predicted tumor yields.
Although we estimated exposure to a specific pesticide that was selected a priori based on toxicity and volume of use, other agricultural pesticides could also be associated with fetal growth.
Arguably, patients are best placed to make decisions about treatment based on toxicity and quality of life, but the latter has not been rigorously studied and/or reported in clinical trials.
Norway started a pesticide reduction plan in 1988 which employed a levied banded tax system based on toxicity at the rate of $3.8 per hectare that resulted in a 54% reduction of pesticide use (PAN, Europe 2004).
The primary objective of the study was to establish a recommended dose level of intravesical Suramin based on toxicity profile and pharmacodynamic end point of VEGF binding.
However, the expected benefit of prolonged anti-hormonal treatment has to be assessed based on toxicity and the individual likelihood of a late recurrence.
The key objective of animal bioassays is to compare toxic potency estimates from analytical-mathematical approaches based on the toxicity of the toxic species analysed in exposure atmospheres.
The former 1 μg/L guideline was based on the toxicity of methylmercury, an organic and highly toxic form of mercury found in the environment [ 105].
