They compared the levels of pesticides to health benchmarks based on toxicity standards from the Environmental Protection Agency.
Based on toxicity findings from another ongoing trial of retaspimycin HCl, this schedule was closed to further accrual and all subsequently enrolled patients received 300 mg/m retaspimycin HCl on the once weekly regimen (see study design and assessments).
A maximum of two dose reductions (from 0.58. to 0.49 then to 0.40 mg m−2) were permitted based on toxicity.
Dose finding was based on toxicity probability intervals [ 14].
In conclusion, the data from our randomised phase II study suggest that individual dose optimisation based on toxicity in the preceding cycle is feasible and merits further investigation.
From these data, doses were selected for the quintary mixture study based on toxicity, survival, range of response, and predicted tumor yields.
Toxicity grading, based on NCIC CTC toxicity criteria (version 2.0, National Cancer Institute of Canada Common Toxicity Criteria, Kingston, ON, Canada), was evaluated weekly.
The key objective of animal bioassays is to compare toxic potency estimates from analytical-mathematical approaches based on the toxicity of the toxic species analysed in exposure atmospheres.
Toxicity grading was based on NCCOG/NCI Toxicity Criteria (NCCOG/NCI, 1991).
Dose modification was based on haematological toxicity and on non-haematological toxicity.
