Sentence examples for based on tolerability and from inspiring English sources

In preliminary experiments we evaluated recombinant human IL-18 at doses from 1 to 100 µg/mouse/day for anti-tumor effects in xenografted mice (data not shown), and 15 µg was chosen as a daily dose based on tolerability and efficacy, and because this dose is less than the equivalent maximum tolerated dose that has been established in monkeys and humans [25], [32].

An increase or decrease in dose was permitted based on tolerability and CGI-S scores assessed by investigators.

An increase or decrease in dose was permitted based on tolerability, and Clinical Global Impression-Severity (CGI-S) scores were assessed by investigators.

Bortezomib doses were 1.0, 1.3, or 1.5 mg m−2, based on tolerability and efficacy in heavily pretreated patients with solid tumours.

Based on tolerability and the proportion of mice with re-emergence of disease, we eventually adopted a protocol consisting of a 4-week block of VXLD, followed at disease re-emergence by a 2-week block of half-dose VXL.

Titration to a higher dose or tapering to a lower dose of MTS was permitted based on tolerability and scores on the Clinical Global Impression-Severity (CGI-S) scale.

Aflibercept 6 mg kg−1 with docetaxel and cisplatin 75 mg m−2 every 3 weeks is the RP2D based on tolerability, antitumour activity, and PKs.

Oral doses of ZD4054 evaluated were 2.5, 10, 20, 30, 60, 120, 150 and 240 mg, with dose escalation continued based on tolerability until the maximum tolerated dose had been defined.

Donepezil was dosed once daily at 2.5 mg and, based on tolerability, increased to 5 mg/day.

Tolvaptan was administered twice daily, starting at a morning/afternoon dose of 45/15 mg and titrated weekly to 60/30 mg and 90/30 mg based on tolerability; subjects could down-titrate at any time to as low as the starting dose (45/15 mg).

After 4 weeks of treatment, both controlled-release and conventional formulations of trazodone (both given at night-time as single daily doses starting at 100 mg and increased to 200 mg/day based on tolerability) were similar in efficacy, as measured by changes from baseline in HAM-D and global assessments of the severity of depression scale scores [ 55].