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We noted that all mitogenomes are in the master circle conformation and all our analyses were based on this conformation.
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Based on the conformation of parent ions, the optimization of product ions was performed in the MS2 scan mode.
The alignment of the molecules was based on the conformation of a structurally related ligand bound to the αIIBβ3 and αvβ3 integrins in X-ray crystallographic studies.
The design of these cyclic compounds was based on the conformation of the HJ loop within the X-ray structure of GRK2.
To develop lower weight BACE1 inhibitors, a series of tripeptidic BACE1 inhibitors were devised using a design approach based on the conformation of a virtual inhibitor bound to the BACE1 active site, also called 'in-silico conformational structure-based design'.
Final G-scores were selected based on the conformation at which the identified ligands formed hydrogen bonds to at least one of the HCR-13pf with optimal binding affinity.
The stereochemical parameters for CKI-7 used in subsequent refinement were based on the conformation of the inhibitor found in the crystal structure of casein kinase 1 (PDB ID 2CSN) [25] in conjunction with values from the energy minimized conformation obtained from the molecular mechanics program MM2 [37], [37] implemented in CambridgeSoft Chem3D software.
Other promising alternative scaffolding methods based on the conformation capture (3C) principle were shown to be efficient for several genomes, including that of the yeast Saccharomyces cerevisiae [ 61].
Third, multiple classes of particles could be sorted based on the conformation of the ribosome and included translating and idle populations.
Therefore, it was suggested, the in vivo proteolytic processing is sequentially regulated based on the conformation of polypeptide or replication complex components [ 36, 37].
The structural restraint file for IP6 was generated using REEL in PHENIX (Adams et al., 2002) based on the conformation of IP6 seen in the structure of Auxin receptor TIR1 (PDB: 2P1P) (Tan et al., 2007).
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