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Based on this collective evidence of the role of IL-2 in Treg function, we hypothesized that reduced IL-2 could be partially responsible for the increased apoptosis and reduced function of Tregs from human T1D subjects.
Thus, based on this collective information, we conclude that CaT1, but not ECaC1, is expressed in Caco-2 cells.
Based on this collective data, we have demonstrated that the 4-species biofilm has reproducible inflammatory properties within an epithelial co-culture model.
We revised the survey based on this collective feedback to clarify wording and add or remove questions based on what reviewers felt was most or least applicable to their own programs and experiences with GTA PD.
Based on this collective evidence, we identified a set of recommendations for and against interventions that are specific to both the setting in which an intervention may be used and the pandemic phase, and which can be used by policymakers to prepare for a pandemic until scientific evidence can definitively respond to planners' needs.
Based on this collective background, we conducted this phase II trial of a sequential nonplatinum triplet combination consisting of three cycles of GEM (100 mg m−2) and VNR (25 mg m−2) followed by three cycles of DOC (60 mg m−2).
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Based on the collective knowledge of this pre-clinical mouse model, the model represents the primary CD8 + T cell response to adenovirus immunization and the subsequent impact on the growth of a tumor derived from the B16F10 cell line.
Based on the collective results from this investigation, we propose a model for the differential effects in cancer cells vs. non-cancer cells of DAC inhibition and DNA damage/repair signaling following ITC treatment (Fig. S8 ).
These strategies are based on the collective clinical experience of this group.
This perspective is based on the collective learning of the authors in reviewing, designing, conducting, and evaluating numerous risk-minimization programs in the USA and EU and their service on several US Food and Drug Administration FDAadvisoryory groups and professional working groups [ 26– 326.
The authors acknowledge that this guidance is based on the collective experience of the group at the time of writing, but it is not definitive, and there is a paucity of previously published data in many areas.
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