Sentence examples for based on these targets from inspiring English sources

Key players, as discussed, include TGFβ and transcription factors, and most current clinically-applicable therapies are based on these targets.

Ablation strategies have been designed based on these targets, mostly incorporating linear lesions to transect putative isthmus sites.

Similar to what we observed in Figure 2, a pan-platform cluster analysis based on these targets yielded 3 major sample clusters corresponding to the 3 cell lines [see Additional file 5].

Traditional analysis employs approximately forty target biomarker compounds [refer to labeled compounds in Additional file 3: Table S2 (in Section S2)], which occur as major peaks dominating the (GCtimes GC) ROI biomarker topography, and about twenty well-known peak ratios [25] based on these target compounds.

Based on these target genes, using the String database, we predicted the miRNA-target protein interactions including direct (physical) and indirect (functional) associations.

41 52 The dosages of the AS-MQ combinations to be administered in this study are based on these target weight dependent calculations and are consistent with current WHO 36 and Malaysian Ministry of Health treatment guidelines (see figure 2).

Based on these putative targets, we were able to map candidate signaling networks to identify any potential network commonalities between the identified targets for each miRNA.

In particular, intra uterine growth retardation (IUGR) has been shown to be associated with both white matter lesions and subsequent neurological impairment [4] [6] Based on these potential targets, a number of treatments for neonatal brain injury including melatonin have been investigated [7].

Studies assessing the impact of implementation of audit instruments document improved consultant practice based on these predetermined targets [ 4].

These differences could be useful as signatures to identify PTCH1 gene carriers at high risk for the development of NBCCS-associated malignancies and to develop novel experimental molecular tailored therapies based on these druggable targets.

Furthermore, a biological signal cascade network was constructed based on these predicted target proteins.