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Other studies have examined the effect of an intervention based on therapeutic exercise in the other two CMSKD and observed differences between the pre- and post-intervention measures comparable to the present study.
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The titration was flexible based on therapeutic response and tolerability.
► Allergen-specific immunotherapy is based on therapeutic vaccination with allergens.
To test whether different types of treatment offer differential benefits, we applied a multiple meta-regression model, whose results enabled us to confirm the initial hypothesis that there are differences in effectiveness between the treatments based on exercise, education, therapeutic physical conditioning and manual therapy, the combination of the latter two being the most promising treatment.
Studies on therapeutic exercises often fail to provide details on the specific exercise techniques used and the exact exercise protocol that was prescribed or followed (e.g. dose, timing, intensity) [ 23].
A community-based physiotherapy lead group exercise program was set up based on successful exercise interventions [ 25, 26].
The Ambient Assisted Exercise Program (AAEP) for iStoppFalls is based on the strength exercise component of the Otago exercise program [ 19].
Contra-indications for exercise testing, based on the Exercise Preparticipation Screening questionnaire or from consultation with the burn physician, may lead to exclusion on the cardiopulmonary exercise test.
The current exercise program is based on the Otago exercise program developed by Campbell and Robertson [ 14] which was also initially developed as a falls prevention exercise program.
The strength exercise program will be based on previously developed exercise programs [ 14], focusing on heavy resistance training and neuromuscular training including one leg exercises and balance training.
Adherence to the exercise program will be calculated based on completion of exercise bouts.
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