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Themes were identified based on their recurrence and/or wider relevance.
We do not seek to report on all of these codes, but following the thematic network analysis procedure as outlined by Attride-Stirling [ 35], identified codes from the larger pool of codes based on their recurrence and interconnectivity with the conceptual frameworks and the reviewed literature, a process that resulted in selection of 32 codes.
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We find that 94.5 % of the ERα-positive Basal-type breast cancer patients are high risk by the MammaPrint assay, making them potential candidates to benefit from chemotherapy based on their high recurrence risk.
Identification and validation of prognostic markers that can stratify patients based on their risk for recurrence and/or death may help in optimizing therapies to improve disease outcomes and quality of life.
Based on their biological functions and recurrence, two of the previously identified deletion alleles disrupting CYP2C19 and CDH19 genes, respectively, were hypothesized to play a role in breast cancer predisposition also in the general population.
Patients with bladder cancer face a variable risk of recurrence based on their clinical characteristics and the biology of their disease.
This method performs both backward elimination of variables and selection based on their importance spectrum, and predicts recurrence patterns in the same set by iteratively eliminating 2% of the least important predictive variables until the current OOB (out-of-bag) error rate becomes larger than the initial or previous OOB error rates.
As illustrated in the upper lines on Figure 1, localization and adjuvant therapy were not associated with the clustering of recurrences based on their specific expression profile.
Although all of these therapies are aimed to prevent metastatic relapse, the selection of patients is at present based on their statistical risk of developing tumor recurrence, without knowing whether they actually harbor any DTCs.
According to the new World Health Organization (WHO) classification in 2005, odontogenic keratocyst (OKC) has been recategorized as a benign odontogenic tumor under the name of keratocystic odontogenic tumor (KCOT), based on their aggressive biological behavior, tendency towards recurrence, and potential of malignant transformation [ 1].
In conclusion, due to the high rate of false positive tests and low positive predictive value of the surveillance program examined, we feel that a more tailored surveillance approach based on recurrence risk and likely recurrence pattern is needed in future CRC surveillance programs.
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