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The five xyloglucan fucosyltransferase genes were categorized into three groups based on their protein sequence similarities (Additional file 9: Figure S2).
Given these alignments we apply support vector regression (SVR) to infer a quantitative measure for the PFM similarity of two proteins that is based on their protein sequences.
Next, superimposing the two structures based on their protein bodies enables us to measure and normalize the conformational difference between these two structures with respect to the swapped domains into the DS score defined here.
Based on their protein architecture and pattern of expression, MDGA proteins have been proposed as a novel subgroup of the IgCAM super family, an important class of membrane proteins involved in cell-cell adhesion, migration and the development of neuronal connections [29].
Both the anti-T1 and anti-T2 antisera recognised bands of approximately 96KD which matches well with the calculated molecular weights for T1 (96 KD) and T2 (98KD), based on their protein sequences and estimated cleavage sites, which separate the α and β chains [45]; the anti-LD1 and anti-LD2 antisera recognised bands of approximately 76KD and 92KD, respectively.
Cells were identified based on their protein expression and/or axonal targets.
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Network analysis of the dataset carried out to identify the most significant sub-network of genes, based on their protein-level interactions, further identified that 3O-C12 inductiof of proinflammatory cytokines occurs in tandem with the upregulation of the classical cytokine transcription factors NF-κB, Fos, and Jun (Figure 2).
The proposed method is expected to be useful for predicting potential side effects of new drug candidate compounds based on their protein-binding profiles.
Using the TSCC method, virtually screened compounds were clustered based on their protein-ligand interactions, followed by structure clustering employing physicochemical features, to retrieve the final compounds.
Thorough analysis of NIA Mouse Gene Index and Mouse Genome Sequence (9 and 10 mm) identified Eif1a (Chromosome 18), Eif1ax (Chromosome X), and a cluster of 19 Eif1a-like genes on mouse Chromosome 12. Based on their protein-coding capacity, we noted 10 Eif1a-like genes (named here Eif1al1– Eif1and0) anineine pseudogenes (named here Eif1al-ps1– Eif1al-ps9; Fig. 3A).
However, the functional similarity between protein complexes in the constructed protein complex network was only based on their shared protein elements.
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based on their grain
based on their content
based on their origin
based on their disease
based on their linkage
based on their enzyme
based on their seed
based on their link
based on their cancer
based on their albumin
based on their la
based on their ninja
based on their lack
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com