Table 3 shows how patients were classified according to their median survivals based on their total prognostic scores.
The 108 paired samples were divided into with-metastasis and without-metastasis two subgroups based on their clinical prognostic features in 3 years following-up investigations.
Patients were assigned to two risk groups based on their cross-validated prognostic index (Fig EV3), successfully stratifying patients on time to relapse (P = 0.00084, log-rank test) (Fig 6A).
Thus, classification of injuries based on their causation may have prognostic validity.
Moltzahn and colleagues evaluated a group of 36 prostate cancer patients stratified into 3 groups of 12 based on their CAPRA score (a prognostic index for prostate cancer), and compared them with a group of 12 healthy controls [ 66].
While the refractory group were likely to be enrolled later after their time of diagnosis, and hence at risk for shorter PFS by definition, we felt that PFS was still a reasonable outcome measure based on their favorable (and similar) prognostic risk.
PMP22 and EMPs were selected for the evaluation of their prognostic values based on their higher expression levels in invasive breast cell lines compared to non-invasive ones.
As these gene clusters were also selected based on their association with cancer development, their prognostic potential in determining overall survival provides a compelling case for future mechanistic studies.
Stratified care for back pain involves targeting treatment to subgroups of patients based on their key characteristics such as prognostic factors, likely response to treatment and underlying mechanisms.
Recent advances in molecular diagnostics allow diffuse gliomas to be classified based on their genetic changes into distinct prognostic subtypes.
