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Since many pathways display redundancy, to certain degree, among themselves, we chose to rank diseases based on their pathway content index (Materials & Methods).
Ye integrated known drug target information and proposed a disease-oriented strategy for evaluating the relationships between drugs and specific diseases based on their pathway profile [ 15].
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The 1206 genera were hierarchically clustered based on their metabolic pathway profiles and 706 metabolic pathways were clustered based on their distribution across the genera (see Figure 2).
In this context, we believe that describing efforts/exercise based on their 'physiological pathway' could lead to mistakes.
Our current study predicted signaling pathway memberships for 5 currently used drug target proteins and suggested 14 additional proteins that can be used as novel drug target candidates, based on their predicted pathway annotations and other properties (Table 2).
This provided us with the opportunity to compare a robust predictor of docetaxel sensitivity across the current dataset of 133 patients that were clustered based on their oncogenic pathway activation status.
Based on their biogenesis pathway, rice miRNAs can be grouped into two classes.
Pathprint provides both a quantitative definition of cellular phenotype and a functional distance between all experiments, based on their global pathway activity.
Further, grouping GBM patients based on their significant pathway perturbations divides them into clinically-relevant subgroups having significantly different survival outcomes.
In the post-genomic era, it has now become clear that known Gram-negative non-flagellar appendages are part of five major classes based on their biosynthetic pathway: chaperone usher (CU) pili, curli, type IV pili, type III secretion needle and type IV secretion pili.
Based on this observation, we set out to investigate disease relationships based on their shared pathways.
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