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To verify this, we divide disease genes based on their onset age as Jimenez et al. [ 25] and compare the Ka/Ks ratio.
We further divided the zygotic genes into four different groups based on their onset of zygotic expression (first time point with FPKM>1).
We further divided the zygotic genes into four different groups based on their onset of zygotic expression—'Early' genes with onset of expression around mitotic cycles 10 11, 'Mid' genes at cycles 12 13, 'Late' genes at early cycle 14, and 'Later' zygotic genes whose onset of expression was during late cycle 14.
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At the peak of the acute phase of disease, the animals were equally distributed to the experimental groups based on their initial onset and severity of disease in order to ensure consistency between each group: vehicle and BAF312 at 0.03, 0.3 and 3 mg kg-1.
There are at least three subtypes of type 1 diabetes based on their mode of onset, i.e., acute onset, slow onset, and fulminant onset, in Japanese patients.
Although there was a single patient of each mutation type in this group, the R165C (FRDA onset at age eight, blind by age 18) 5 and W155R (onset at age four, death by age 18) subjects had frataxin levels far greater than that expected based on their age of onset and clinical severity.
Then, within each TLE group, we categorized patients based on their age of seizure onset (SO) into two subgroups: early/childhood or late/adult age of seizure onset.
Our data provide some evidence that the early pathological stages of ALS may be on a continuum based on their mean age at onset and increasing disease duration (Additional file 5: Figure S5).
Most epilepsies can be broadly and easily classified based on their pattern of electroclinical onset as either generalized ('originating at some point from within, and rapidly engaging, bilaterally distributed networks') or focal ('originating within networks limited to one hemisphere') [ 1].
The authors examined the longitudinal relationships between key cognitive domains, selected a priori based on their association with schizophrenia, and onset of psychotic experiences in children from the Avon Longitudinal Study of Parents and Children and whether these associations were independent of one another.
As might be expected, absolute CAD event rates were highest in the high-risk GeneSTAR cohort based on their ascertainment from an early-onset CAD proband and lowest in the population-based NHANES cohort.
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