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Since all of the 28 SCZ drugs involved in the 991 interactions belonged to the "nervous systems" category, we grouped the 991 interactions into 14 categories based on their interacting drugs' ATC first-level annotation.
The authors named the sites H (Hoechst33342) and R (rhodamine 123) based on their interacting ligands.
Pathway ontology analysis was undertaken to characterise groups of genes altered during prostate differentiation based on their interacting biological function.
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BAG3 belongs to the evolutionarily conserved BAG family of proteins that were originally isolated based on their ability to interact with the anti-apoptotic protein Bcl-2 [36], [36].
Indeed, it is thought that as much as 60% of breast cancer has an environmental etiology [4], [6], with strong toxicological evidence linking a number of ubiquitous environmental contaminants to breast cancer based on their ability to interact with or disrupt hormone signalling pathways or alter mammary gland development, thus altering susceptibility to mammary carcinogenesis [7], [8].
The level of consciousness of patients who survive severe brain injury is assessed clinically based on their ability to interact with the environment and communicate.
The immunostimulatory effect of ecto-HSP70 and 90 is based on their ability to interact with several APC surface receptors [ 105 ], for example, CD91, LOX1, and CD40 [ 106 ], and to elicit CD8+ T-cell response by participating in cross-presentation of tumor-derived antigens on MHC class I molecules [ 107 ].
Recognizing the pivotal role of lymphocytes in orchestrating the body's immune response against infection, based on their ability to interact with cells of innate and adaptive immune system, it might be possible to decrease mortality in sepsis by therapies to augment host immune response through restoring lymphocytes function.
Therefore, there is an increasing trend towards the use of bio-analytical techniques that allow detecting specific groups of chemicals based on their common properties to interact with specific biological processes/pathways [31].
Interacting genes were sorted based on their total number of SL interactions regardless of interaction strength.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com