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For each BC cell line, a weighted mean expression of genes present in the respective signature was determined, and cell lines were ranked based on their concordance.
These interventions can target patients most at risk for suboptimal care based on their concordance and discordant conditions, if future work shows that patients with certain multimorbidity profiles are more at risk than others.
However, the 80 genes profiled in that assay were selected using fresh frozen tissue to classify tumors as Luminal-type, HER2-type, or Basal-type based on their concordance to ER, PR and HER2 IHC values.
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To test this hypothesis, we filtered the 180 genes based on their directional concordance between the training data (NSCLC cell lines) and the CRC data.
We created a final selection of 616,201 high quality variants based on their assay performance, physical distribution, and concordance with in silico variant calls from sequencing data.
This allowed us to obtain a simple classification of DEGs into "coupled" or "uncoupled", based on the concordance of their variation between the transcriptome and the translatome.
The educational intervention consisted of two sets of two clinical-based scenarios written based on script concordance theory.
Two measures of degree of explanation were provided by the SAS logistic procedure, one based on concordance between observed and model computed results, the other based on the receiver operator characteristics (ROC) method.
A monophyly-based species concept will not do, nor will a concept based on genealogical concordance at multiple loci apply, at least strictly.
We sought to develop a valid, reliable assessment of intraoperative judgment by residents during gynecologic surgery based on Script Concordance Theory.
Based on genomic position, a total of 107,896 SNP were shared between the 2 platforms; however, based on genotype concordance, only 96,031 SNP had complete concordance at these loci.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com