As for any Mendelian conditions, the definitive genetic diagnosis of HRFs is based on the finding of unambiguous mutations in the causative genes.
Multiaxial high cycle fatigue criteria based on the critical plane approach necessitate unambiguous definitions of the amplitude and mean value of the shear stress (τa and τm) acting on the material planes.
The identification of the metal ion as a divalent zinc atom was unambiguous based on the electron density maps generated from the multiple anomalous data.
As in the original analysis [ 32], support for backbone branches is effectively unambiguous based on the concatenated data, and the outgroup-inferred root is placed between Osmundastrum and the remainder of the family, resolving the traditional genus Osmunda (Osmunda s.l).l
The mock assignment procedure was performed by first declaring an assignment as being unambiguous if, based on the known assignments from the BMRB, there was one and only one match between an internal chemical shift in a spin system and a sequential chemical shift in another spin system within a "resolution" window.
Furthermore, it might be difficult to obtain unambiguous inference based on the cell division data alone.
In many subjects, RCCX combinations were unambiguous merely based on the set of ASLR-PCRs, taking all conceivable RCCX haplotypes into account.
The purpose of this was to increase the completeness of the data supermatrix, and was only done for genera with unambiguous monophyly (based on the analysis of the species-level data supermatrix).
We developed procedures to obtain unambiguous personal genotypes based on the mining of three independent genotype datasets: 1) The 1000 Genome Project imputed phased SNPs (Broad Institute, version 20100804); 2) The 1000 Genome Project imputed phased indels (Broad Institute, version 2010_07); 3) Bi-allelic CNV calls as described [ 30].
The approach is based on the realization that fatigue requires two load parameters for unambiguous description.
