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Primers based on the tk and vgf nucleotide sequence of VACV WR were produced as described by Fonseca et al. [24].
The primers based on the TK and VGF nucleotide sequence of VACV WR were produced as described by Fonseca et al. (6 ).
Phylogenetic trees based on the TK and the portion 3 L of chemokine analogue receptor of interleukin IL8 sequences are shown in Figure 3 and Figure 4.
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Another appealing reason is the fact that new approved therapies for those cancers are targeting EGFR, based on the inhibition of its TK activity (Baselga, 2002; Jimeno and Hidalgo, 2005).
One previous study also suggested that P. infestans might contain a TK based on the clustering of an EST-derived sequence with TKs, albeit with weak branch support [ 42].
As described above, the sensitivity and specificity of I-FIAU on cancer detection is based on the expression of HSV1-tk reporter gene in the transduced cancer cells.
The concept of [18F]FEAU PET imaging with NV1023 is based on the ability of the HSV-1-tk reporter gene, to catalyze the phosphorylation of the thymidine analog [18F]FEAU.
Most molecular probes for HSV1-tk are based on the structure of ganciclovir, which has a molecular weight of 255 Da and only achieves a concentration in the brain of about 50% of the plasma level [ 49].
To assess if TEMs are required for the maturation of collateral arteries and thus preadaptation to ischaemia in Phd2+/− mice, we used a suicide gene strategy based on the Herpes simplex virus thymidine kinase (tk -ganciclovir (GCV) systk -ganciclovirefore (Capobianco et al, 2011; De Palma et al, 2003, 2005; Welford et al, 2011).
Patrick: The Irish Legend," which has its premiere on Thursday (Fox Family Channel, tk p.m ., is based on the autobiographical writings of the fifth-century saint, who was born into a noble family in Roman Britain, kidnapped by pirates, then sold into slavery in pagan Ireland, from which he eventually escaped with the help of divine guidance.
Combination of HSV1-tk and PET imaging is based on the virtues of vectors which can carry and selectively express the HSV1-tk reporter gene in a variety of cancer cells but not in normal tissue.
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