Based on the 68 tender joint count and 66 swollen joint count an ACR20 response for improvement 24 was observed in 5 patients after 4 weeks of adalimumab treatment (of which 4 also fulfilled the ACR50 response criteria), but in none of the placebo-treated patients.
The DAS28 score was based on the number of tender and swollen joints out of 28 joints, the erythrocyte sedimentation rate (ESR) and the patient's general health measured on a visual analogue scale (VAS) of 100 mm [ 23].
Based on the 1999/2000 state tender prices for the DMPA and NET-EN innovator products, the cost per couple year was SAR28.68 for NET-EN (6 vials per year) and SAR19.12 for DMPA (4 vials per year).
Assessment of disease activity is based on the count of tender and swollen joints, the measurement of erythrocyte sedimentation rate (ESR) or serum levels of acute phase reactants such as C-reactive protein (CRP), and the pain score of patients [ 1- 3].
Based on the number of positive tender points in controls, the cutoff value of tender point count for pressure hyperalgesia responders was 7. Of the 176 subjects, interictal widespread pressure hyperalgesia and acute allodynia were observed in 74 (42%) and 115 (65.3%) patients, respectively.
The DAS28 based on three components including C-reactive protein (DAS28(3)CRP) was calculated based on the 28 swollen and tender joint count and CRP value.
The government's intention was to tender the entire project, based on the British design, as a single tender at a fixed price.
The DAS28 score was calculated based on the results of the 28 tender joint count (TJC), 28 swollen joint count (SJC) and ESR, as well as the patient's global health, as represented by the visual analog scale (P-VAS).
The DAS28 was calculated based on the swollen joint count (SJC), tender joint count (TJC), erythrocyte sedimentation rate (ESR), and the patient's global health assessment on a visual analogue scale (VAS).
Calculations of the DAS28 and SDAI are based on the following: numbers of swollen and tender joints (swollen joint count [SJC] and tender joint count [TJC]), employing the 28 joint count; evaluator's and/or patient's global assessment of disease activity (EGA, PGA and CRPRP or ESR.
