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Therefore, these results open the perspective of a therapy of the anaplastic thyroid carcinoma, one of the most aggressive tumours in mankind, based on the suppression of the UbcH10 synthesis and/or function.
The data suggest a transient mechanism based on the suppression of fuel adsorption onto bubble lamellae surfaces due to the oleophobicity of fluorocarbon surfactants, which is consistent with fuel solubility data.
An understanding of the molecular mechanisms of aromatase expression between non-cancerous and cancerous breast tissue, at the transcriptional level, may help in the design of a therapy based on the suppression of aromatase expression in breast cancer tissue.
Pharmacologically, they also displayed diminished PPARγ binding and ap2 gene expression in a mouse pre-adipocyte cell line 3T3-L1, but enhanced anti-cancer properties based on the suppression of liver cancer cell line (Huh-7) proliferation and the expression of tumor marker, afp.
Male hormonal contraception, based on the suppression of both gonadotropins, follicle-stimulating hormone and luteinizing hormone, resulting in marked decrease in sperm production, is designed for couples in stable relationships where the male partner desires to assume family planning responsibilities using reversible methods.
The entire livelihood system of Soqotran pastoralists, or put differently their consumer attitude, is based on the suppression of the desire for consumption and the forced adoption of an ethic of renunciation.b The motto of this ethic can be formulated in a paraphrase of Gudeman's ([1978] 40) characterization of the consumption ethic of peasant farmers: self-maintenance over self-indulgence.
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Polarizers belonging to the first class are based on the coherent suppression of phase noise, which is intimately related to the incoherent nature of light beams.
Based on the recombination suppression, a new photoelectrochemical strategy was developed for the selective detection of dopamine.
For example, the relative extent of intermolecular (between adjacent lipids) and intramolecular (within a specific lipid) polymerization is uncertain, but based on the oxidation suppression results, intermolecular polymerization must be significant to form such an effective protective barrier.
Experimental evidence is based on the successful suppression of 5'Nuc transcription in the tsetse salivary gland by RNA interference and on the production of functional recombinant protein with characteristics that are nearly identical to the native activity.
From these results, our objective was to develop a novel therapeutic strategy for axonal regeneration, based on the targeted suppression of astroglial reactivity and scarring by lentiviral-mediated RNA-interference (RNAi).
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