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They were matched based on the subtypes, gender, and age (Table 1).
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Subtype was assigned centrally based on the Subtype Classification Using Evolutionary Algorithms (SCUEAL) [13], which uses model-based phylogenetic methods to assign viral subtype.
We have found that SOSIP gp140 proteins based on the subtype A HIV-1 strain KNH1144 form particularly homogenous trimers compared to a prototypic strain (JR-FL, subtype B).
The split was based on the subtype of the virus.
In this study, however, it was not possible to set up a blocking ELISA based on the subtype-specific HA peptide antigens and the rabbit sera as source for indicator antibodies.
Next, we stratified the patients based on the subtype of GBM.
These classifications were determined to be clinically relevant when it was demonstrated that there were significant differences in survival based on the subtype.
The fact that these subtypes appear quite distinct on the molecular level suggests not only that the molecular processes driving tumorigenesis can vary among patients but also that the treatments may have to be tailored based on the subtype of tumor a patient has.
The St. Gallen International Conference 2013 proposed practical subtypes based on the intrinsic subtypes, and recommended specific treatments.
We developed a classifier based on the molecular subtypes (C1, C2, C4, C5) identified in our previous study of 215 tumours from the Australian Ovarian Cancer Study (AOCS) [5].
Moreover, subgroup analyses were also conducted based on the various subtypes of lymphoma.
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