Sentence examples for based on the substrate from inspiring English sources
Although they share little sequence identity, around 120 members have been classified (EC 2.1.1.X), based on the substrate specificity and on the atom targeted for methylation [58].
We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors.
Using a cell-based assay, based on the substrate competitive EHMT2 inhibitor BIX01294, we have identified proof-of-concept compounds that induce re-expression of a subset of genes consistent with dual HKMT inhibition.
Based on the substrate specificity, models for the recognition of inositol by the enzyme were proposed.
The enzymatic saccharification was performed at 5 FPU g−1 based on the substrate.
Based on the substrate specificity, 3-hydroxyalkylidene- and 3-carboxyalkylidenemalate derivatives were designed as a specific inhibitor for homoisocitrate dehydrogenase.
The closed-form model predicts the expected value and the variance of the thin film properties based on the substrate temperature during the deposition process.
Based on the substrates, GA2ox proteins can be divided into two groups, one group, known as C19-GA2ox proteins, using bioactive C19-GAs and C19-GA precursors as substrates, while the other group, known as C20-GA2ox, acting on C20-GA precursors [ 15, 22, 23].
Another variation of the antisense concept, which is discussed in this chapter, is based on the substrate-recognition properties of the ubiquitous enzyme ribonuclease P (RNase P).
It is well known that mechanisms exist for controlling the targeted degradation of specific proteins, for example, based on the substrate-specific action of E3 ligases targeting proteins for degradation by the proteasome (King et al., 1996).
In this study we define the catalytic G-domain interface by mutagenesis and present a structural model, of how GTP hydrolysis is activated in Irga6 complexes, based on the substrate-twinning reaction mechanism of the signal recognition particle (SRP) and its receptor (SRα).
