Sentence examples for based on the splice from inspiring English sources

It also provides two types of putative splicing regulatory factors, one is based on SR proteins and the other is based on the splice site.

Since our transcriptomes are reconstructed from a non strand-specific RNA-seq dataset, we determined the direction of transcripts based on the splice junction sequences.

Previously we have shown that Oli-neu cells, when grown under the same conditions used here (i.e., differentiation medium), may be moving toward the immature oligodendrocyte stage based on the splice variants expressed for mPlp1 and other myelin-related genes including myelin basic protein (Mbp) and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Cnp) (Pereira et al., 2011).

The design of both primers was based on the splicing sequence.

A program built in-house based on the "Splicing Index" model was used to detect differentially expressed exons.

Based on the splicing junctions identified from our datasets using HMMSplicer [ 37], we found evidence for antisense spliced junctions in 123 of the 1247 genes with NATs (Additional file 11: Table S5).

Based on the splicing patterns, nine AS events (as defined in DEDB [ 4] and ASD [ 1, 2]) have been identified in the chicken genome and compared to those in human and mouse.

The most predictions came from Human Splice Finder (3788 SNP-transcripts, average difference 16.19%), followed by a neural network splice site prediction tool, NNSplice (3142 SNP-transcripts, average difference 31.03%) and the least from NetUTR (1468 SNP-transcripts, average difference 37.26%), based on the NetGene2 splice prediction tool and trained on a data set of UTR splice patterns.

Once the putative exons had been identified for a specific gene homolog, the exon start and end positions were manually corrected based on the canonical splice site donor/acceptor sequences and the overlapping sequence from one putative exon to the next.

We scored RP-sites based on the human splice junction consensuses as shown in Figure 1.

These computations were also based on the human splice junction consensuses with the assumption that 5'- and 3'-intron termini (GT or AG dinucleotides respectively) must be present in the RP-site motifs.