The phrase "based on the speculation" is correct and usable in written English.
You can use it when conveying an idea that is rooted in an assumption or hypothesis, rather than on an established fact. For example: "The forecast calls for rain later this week, but we can't be sure of the forecast's accuracy, so any decisions should be made based on the speculation."
Accordingly, in the present study we used data for our analyses based on the speculation that they were the same as those obtained when tablets were given to patients.
Our postulate is based on the speculation that the potency of binding will be increased upon cyclo-aromatization reaction due to increased π-stacking interaction.
Subsequently, two alternative non-Taq formulations were evaluated, based on the speculation that they could be more resilient to higher quantities of SYBR Green I.
This is based on the speculation that, in signaling pathways, the capacity of a protein to interact with upstream agents depends on the relative frequency of co-occurrence and the interaction strength with those agents, which is this case, is represented as the PSF signals of the source nodes.
The regions shown in Figure 6A and 6B were chosen based on the speculation that profile-1 genes (silenced from day 7 to day 28) might be trans-activators of γ-globin expression since they are expressed in a similar pattern as other factors demonstrated to activate γ-globin.
Numerous pairs of opposites (male-female, diurnal-nocturnal, hot-cold, and others), based on the speculations of the followers of Pythagoras, a Greek mystical philosopher of the 6th century bc, are connected with consecutive pairs of signs.
Based on these speculations, the present study attempted to confirm our previous observations in a larger number of cases, to determine whether focal disruptions of myoepithelial cell layers is a prevalent event, and whether all the cell clusters overlying focally disrupted myoepithelial cell layers have the same morphological and immunostaining feature.
Second, the value of those trades was largely based on the traders' own speculation, in an environment where the traders' bosses were rewarded for higher reported profits.
Our initial working hypothesis, based on the prior observations and speculation (Gems, 2007), was that many XME genes would be elevated in both males and females of the DR and rapamycin groups.
It must draw defensible conclusions, based on the evidence (and not speculation), and must make responsible recommendations.
Soon after the Hoxne Hoard was discovered, there was speculation, based on the name "Faustinus" engraved on one of the spoons, that it may have come from the "Villa Faustini" that is recorded in Itinerary V of the Antonine Itinerary.
