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Based on the scaffold results, GRAS would be the least diverse data set.
Scaffvis is a client-sever application which enables to interactively explore molecule data sets based on the scaffold hierarchy.
The genome sequences of Pseudomonas stutzeri TAIHU and Mesorhizobium sp. TAIHU, can be retrieved from the assembly based on the scaffold list belonging to each species in Additional file 1: Table S7.
While Scaffold Hunter provides visualization based on the Scaffold Tree (as well as on hierarchical clustering), the scaffolds in Scaffold Explorer are defined interactively by the user at the time of performing the interactive analysis.
Two series of novel EPAC antagonists are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit 1 (ESI-09).
Based on the scaffold of 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-dione, a series of L-shaped derivatives with substituted side chains at the position of C2 were designed by analyzing the binding mode with NQO1.
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Since metabolites and NPs are already optimized by millions of years of evolution to bind to at least one biological macromolecule therefore, it is highly likely that libraries designed based on the scaffolds and fragments occurring in metabolite and NP space will result in molecules with better ADMET properties.
First, RepeatMasker V3.3.0 (http://www.repeatmasker.org/) was applied against the Repbase library (species Anopheles) based on the scaffolds.
Based on the scaffolds of JIII-386, possible connections between contigs within the assemblies of MAP S397 and CLIJ361 could be determined (see supplementary table S8) which might be helpful for further improvement of these assemblies.
Based on the scaffolds with which these markers were associated, and the chromosome locations of other mapped markers from the same scaffold, the chromosome locations of these 33 markers on the CSS-F2 map constructed herein were considered correct and were assigned to the consensus map (Additional file 2: Table S7).
Based on the scaffolds with which these markers were associated and their map locations on different genetic maps, the chromosomal locations of SSR01981, SSR02693, SSR04454, and SSR04905 on the CSS-F2 map, and SSR19728, SSR21834, as we all as CMCT160a on the CSS-RIL map were considered correct.
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